In order to get the platinum trophy I would suggest playing the game twice (since trying to achieve it in only one run could be suicidal).
Focus on the non-difficulty related trophies on the first playthrough.Trophies like the tonic collector one and slots are ADAM wasters so do that on normal difficulty where you can beat the game without actually improving your health. Also be careful with the research/pictures of bots, cameras and turrets since those don’t have individual bronze trophies (I almost fucked up actually) and you won’t know if you completed their research if you don’t check yourself.
Now for the survivor difficulty level trophies (remember to turn off vita chambers in options when you begin the game):
-Save very often, you don’t wanna repeat doing some stuff just because you didn’t save.
-You don’t need more than 4 plasmid slots, so don’t waste ADAM on the 5th. Telekinesis, Security Bullseye, Enrage and Hypnotize Big Daddy are the plasmids you should have in hand aside from the electric one.
-Chemical thrower is your friend, electric gel beats the crap out of the big daddies, the napalm works well on splicers and the icy one is way better than the electric plasmid to deal with turrets and cameras.
-Upgrade chemical thrower, grenade launcher and crossbow first! those are the most useful weapons against big daddies.
-While you won’t be needing the whole 5 plasmid slots, you will be needing the tonic slots, so buy them.
-Remember that human inferno tonic makes fire related weapons more ass kicking and electric flesh does the same with electricity related weapons (which makes a great combo with electric gel on big daddies).
-Oh yeah, take pictures of every enemy! It will make this run much more easy, and if you combine that with the research tonic, you’ll be kicking ass.
Well those are the essential tips, gamefaqs has more in-depth guides and tips if you’re looking for any.
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